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KMID : 0356920120620050461
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Korean Journal of Anesthesiology
2012 Volume.62 No. 5 p.461 ~ p.467
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The effects of hydrogen sulfide under sevoflurane administration against ischemia and reperfusion injury in isolated rat heart
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Lee Dong-Kyu
Lim Sang-Ho
Kim Nan-Suk
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Abstract
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Background: Hydrogen sulfide (H2S) produces a protective effect against myocardial ischemia and reperfusion injury. Sevoflurane, which is used for anesthesia in cardiac problem patients, also has a protective effect. This study is designed to reveal the effects of H2S under sevoflurane using rat hearts.
Methods: The hearts were Langendorff-perfused, subjected to 30 minutes ischemia and 60 minutes reperfusion. Group I was a control group. The other groups were pretreated for 15 minutes before ischemia as follows: 1.6% sevoflurane for group S; 18.5 μM H2S S for group H; and 1.6% sevoflurane and 18.5 μM H2S simultaneously for group HS. Hemodynamics and the infarct size were measured.
Results: Group HS presented depressed hemodynamics during pretreatment. LV function in group HS achieved better recovery than group I after reperfusion. The infarct size of groups S, H and HS was smaller than group I, while there were no differences between groups S, H and HS.
Conclusions: Exogenous H2S did not enhance the preconditioning effects of sevoflurane. Rather, the results suggest that H2S under sevoflurane might depress hemodynamics.
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KEYWORD
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Heart, Hydrogen sulfide, In vitro, Ischemia, Reperfusion injury, Sevoflurane
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